Canadian Journal of Applied Sciences <p align="justify"><span style="font-size: 9pt;"> Canadian Journal of Applied Sciences (ISSN: 1925-7430) is an accredited online journal starred in 2011 and. The journal covers a wide range of life and biological sciences and publishes the accepted manuscripts yearly basis. The biological or life sciences comprised of study of life and organisms. Life sciences discoveries are helpful in improving the quality and standard of life, and have applications in health, agriculture, medicine, pharmaceutical and food science industries.</span></p> en-US <ol start="1"><li><strong>Copyrights</strong>:Authors who publish in ICDTD Incjournals retain copyright to their work. Submission of a manuscript to the respective journals implies that all authors have read and agreed to the content of the Covering Letter or the Terms and Conditions. It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere.ICDTD Inc(Licensor) grants the author(s) a worldwide, royalty-free, non-exclusive, and non-commercial perpetual license to exercise the rights in the article published as stated below:</li><ol start="1"><li>All articles are published under the Creative Commons Attribution License (, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided that the work is properly cited.</li><li>The authors retain the copyright of their published article. They will also have the right to:</li><li>Reproduce the article, to incorporate the article into one or more collective works, and to reproduce the article as incorporated in collective works;</li><li>Create and reproduce Derivative Works for educational purposes.</li><li>Distribute Copies</li></ol></ol>Any commercial application of the work, with prior agreement by the author, is exclusively granted to ICDTD Inc. (Support Manager) (Technical Support Staff) Thu, 10 Jun 2021 00:00:00 +0000 OJS 60 ANESTHETIC AND ANTIBACTERIAL ACTIVITY OF KETAMINE DERIVATIVES SYNTHESIZED BY MANNISH REACTION <p><strong>Background</strong>: The present study focuses on the anesthetic and antibacterial effect of ketamine which is a commonly used general anesthetic.</p><p><strong>Methods</strong>: Five derivatives of ketamine i.e. Rxn-102, Rxn-103, Rxn-113, Rx-601, and Rx-801 were parepared. The Anesthetic activity of ketamine derivatives was determined using tail immersion test and the results were compared with ketamine. For biological activity of the antimicrobial complexes, Agar plate dilution test was performed in order to evaluate the Minimum Inhibitory Concentration (MIC) of ligand and newly synthesized derivatives The antibacterial effect of ketamine was studied using six different strains of bacteria (Staphylococcus aureus, Staphylococcus epidermidis, Entecoccus faecalis, Streptococcus pyogenes, Pseudomonas aeruginosa and Escherichia coli). Ciprofloxacin was used as a control to verify the methodology.</p><p><strong>Results</strong>: Comparison of the tail immersion and formalin tests data indicated that derivatives had comparable anesthetic activity to that of Ketamine. The antibacterial effects of all compounds were relatively lower than ciprofloxacin. The derivatives Rxns 102, 113, 103, 601 and 801 demonstrated better effects on bacterial strains of S. aureus and S. epidermidis. However, only Rxn 113 showed better results against E. faecalis.</p><p><strong>Conclusions</strong>: Ketamine not only showed profound anesthetic action but also had a strong inhibitory effect on growth of gram positive bacteria Staphylococcus epidermidis</p><div></div> Syed Muzzammil Masaud, Ghulam Abbas Miana, Taha Nazir, Saeed Ur Rasheed Nazir, Misbah Sultana, Safia Sultana Munir, Humayun Riaz, Pervaiz A Shah, Haider Abbas Zaidi Copyright (c) 2021 Canadian Journal of Applied Sciences Wed, 09 Jun 2021 00:00:00 +0000