SYNTHESIS, SPECTRAL CHARACTERIZATION OF SCHIFF BASE TRANSITION METAL COMPLEXES: ACHE INHIBITOR, ANTIOXIDANT AND ANTIMICROBIAL ACTIVITY STUDIES
Authors: K. H. Kumar Naik a , B. Ashok a , Avinash Prakashab , Nagaraja Naika *
Keywords:

Schiff bases, Metal complexes, Enzymatic activity, DPPH Assay, Antimicrobial
activity.

Abstract

In the present study, we synthesized Novel ligand and their metal complexes with 8-((2-(2,4-
dinitrophenyl)hydrazono)methyl)-7-hydroxy-4-methyl-2H-chromen-2-one ligand. The colored
complexes were prepared by the addition of chloride salts of Manganese(II), Cobalt(II),
Nickel(II) and Copper(II) to a solution of ligand. In conclusion, the structures of the obtained
complexes were characterized by FT-IR, elemental analysis, UV-spectral studies, conductmetric
and magnetic susceptibility measurements. The synthesized metal complexes were investigated
for biological activities. Enzymatic inhibition activity has been done by using
acetylcholinesterase (AChE) enzyme, antioxidant activity by DPPH assay and also the
antimicrobial studies. All tested metal complexes and ligand reveal effective biological activities.

Article Type:Original research article
Received: 2013-10-05
Accepted: 2013-10-15
First Published:9/29/2024 6:29:13 AM
First Page & Last Page: 90 - 107
Collection Year:2013