Abstract

Almost 21.6 million people are infected and 200,000 people killed by typhoid fever each year. This study was intended to evaluate the importance of serum levels of C-reactive protein and cholesterol to determine their correlation with typhoid disorder. In a prospective study, 50 patients were clinically diagnosed as typhoid patients by ELISA method and evaluated as per criteria for serum levels of cholesterol, CRP, Immunoglobulin G and Immunoglobulin M. These patients were compared with 20 healthy controls. The data was analyzed for finding the significance of serum cholesterol and CRP in typhoid.All parameters were found to be highly significant with typhoid and showed high degrees of variations with controlled population. P- Values were less than 0.05 for all parameters. Highest correlation was seen between Immunoglobulin M and CRP.So, in light of our findings, CRP and cholesterol have a strong impact of typhoid diseaseand appear as disturbed markers in worsening condition of typhoid. Consequently, patients coming with typhoid disorders must also be examined for any commotion in these two markers so that the culprit cause may be removed and patients could effectively be treated against secondary threatening ailments.