Abstract

Ribavirin are used for the treatment of chronic hepatitis C with compensated liver disease, in the present study we manufactured the new formulations of Ribavirin capsules by using Microcrystalline cellulose PH 102, Di-calcium phosphate, Povidone K 30, Crospovidone, Aerosil 200 and Magnesium stearate. This study is alienated into two phases. The first phase of the study comprises of new formulation of Ribavirin capsules which were prepared. Whereas in the 2nd phase of study new formulation is evaluated for their physical parameters like average weight, weight variation, disintegration time and also evaluated the chemical analysis like dissolution behaviour and assay. All quality control parameters: average weight, weight variation test, disintegration test, dissolution test and assay were carried out specified by BP/USP (British and United state Pharmacopoeia) for capsules. The results showed that all parameters of new formulations are in accordance with the BP/USP limits.